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Talk Python To Me

Michael Kennedy

Talk Python to Me is a weekly podcast for Python developers, data scientists, and AI builders, hosted by developer and entrepreneur Michael Kennedy. We dive deep into the packages, tools, and people shaping Python, from web development and data science to AI and LLMs. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from its leaders. And if you've been Pythoning for years, you'll hear about your favorite packages and the hot new ones coming out of open source.

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  1. #567: Personal AI Agents for Pythonistas 1:06:38
  2. #566: State of the art in Python 2026 1:05:13
  3. #565: Tachyon, Python 3.15's Built-in Sampling Profiler 1:27:46
  4. #564: EVE Online Departs for Python 3 1:07:52
  5. #563: Getting Started with Rust as Python Devs 1:10:50
  6. #562: DuckLake: The Lakehouse That's Just SQL and Parquet 1:11:09
  7. #561: TonIO, a Multi-threaded Async Runtime for Python 1:15:47
  8. #560: Building a Research OS: From Django to 30,000 Samples 1:02:49
  9. #559: 12 Things You Should (and Shouldn't) Do in AWS 1:07:51
  10. #558: Hyper-Personal Software with Python 1:02:13
  11. #557: Security of everything at PyCon 2026 1:08:00
  12. #556: Updates on Django's Async Story 1:04:56
  13. #555: Marimo Pair - A Canvas for Agent + Developers Collaboration 1:04:59
  14. #554: Trustworthy AI in Healthcare and Longevity 1:00:40
  15. #553: All of our tools 55:15
  16. #552: Astral joins OpenAI 1:05:08
  17. #551: Stroll Down Startup Lane - 2026 1:48:54
  18. #550: AI Contributions and Maintainer Load in Open Source 1:02:42
  19. #549: Great Docs 1:07:00
  20. #548: Event Sourcing Design Pattern 1:08:49
  21. #547: Parallel Python at Anyscale with Ray 59:16
  22. #546: Self hosting apps for Python people 1:03:12
  23. #545: OWASP Top 10 (2025 List) for Python Devs 1:06:03
  24. #544: Wheel Next + Packaging PEPs 1:11:17
  25. #543: Deep Agents: LangChain's SDK for Agents That Plan and Delegate 1:03:53
  26. #542: Zensical - a modern static site generator 1:04:03
  27. #541: Monty - Python in Rust for AI 1:05:44
  28. #540: Modern Python monorepo with uv and prek 1:02:13
  29. #539: Catching up with the Python Typing Council 1:01:41
  30. #538: Python in Digital Humanities 1:12:27
  31. #537: Datastar: Modern web dev, simplified 1:16:37
  32. #536: Fly inside FastAPI Cloud 1:07:00
  33. #535: PyView: Real-time Python Web Apps 1:07:56
  34. #534: diskcache: Your secret Python perf weapon 1:14:00
  35. #533: Web Frameworks in Prod by Their Creators 1:01:58
  36. #532: 2025 Python Year in Review 1:18:32
  37. #531: Talk Python in Production 1:21:13
  38. #530: anywidget: Jupyter Widgets made easy 1:11:21
  39. #529: Computer Science from Scratch 1:17:00
  40. #528: Python apps with LLM building blocks 1:16:46
  41. #527: MCP Servers for Python Devs 1:06:25
  42. #526: Building Data Science with Foundation LLM Models 1:07:24
  43. #525: NiceGUI Goes 3.0 1:17:46
  44. #524: 38 things Python developers should learn in 2025 1:09:15
  45. #523: Pyrefly: Fast, IDE-friendly typing for Python 1:07:00
  46. #522: Data Sci Tips and Tricks from CodeCut.ai 1:09:32
  47. #521: Red Teaming LLMs and GenAI with PyRIT 1:02:40
  48. #520: pyx - the other side of the uv coin (announcing pyx) 1:00:11
  49. #519: Data Science Cloud Lessons at Scale 1:02:56
  50. #518: Celebrating Django's 20th Birthday With Its Creators 1:08:13