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Base by Base

Gustavo Barra

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time.Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

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Episódios

472 episódios

  1. 471: How cancer treatment picks winners among mutant clones in the normal esophagus 17:54
  2. 470: The hidden swaps CRISPR leaves between sister chromosomes 17:23
  3. 469: What the shape of a face reveals about cleft risk 18:17
  4. 468: When a splicing factor breaks in different ways 17:30
  5. 467: Finding mutations carried by fewer than 1 in 100 cells 18:37
  6. 466: A quieter MECP2 switch and the male bias in autism 18:45
  7. 465: When a lysosomal storage gene shows up only in the retina 20:03
  8. 464: Burning fat while sparing muscle on GLP-1 drugs, in mice 18:20
  9. 463: Why brain traits leave faint, common genetic signals 18:21
  10. 462: A vessel gene tied to AMD dims low-light vision in mice 20:10
  11. 461: Adult Ank3 loss quiets neurons and lowers a myelin protein 24:55
  12. 460: The lupus variant that also sharpens antiviral defense 24:13
  13. 459: Cerebral palsy genetics: 515 candidate genes, evidence for 89 24:06
  14. 458: Somatic or inherited? Reading TP53 risk from shared DNA 25:09
  15. 457: A deletion that raises Alzheimer risk, a duplication that lowers it 24:15
  16. 456: Beyond exons: where heritability hides as traits get more polygenic 45:46
  17. 455: Agentic genomics: the bottleneck moves from code to judgment 13:44
  18. 454: Efavirenz retarda a doença priônica mexendo no colesterol do cérebro [PT] 17:13
  19. 453: Efavirenz slows sCJD progression by reshaping brain cholesterol 20:56
  20. 452: Reduzir a PrP funciona em todas as linhagens [PT] 28:42
  21. 451: Prion protein lowering is disease-modifying across stages and strains 24:36
  22. 450: ASOs que reduzem PrP prolongam a sobrevida [PT] 24:57
  23. 449: siRNA divalente para doença priônica [PT] 28:46
  24. 448: PrP‑lowering ASOs prolong survival in prion‑infected mice 25:16
  25. 447: Divalent siRNA for prion disease 23:33
  26. 446: Cilia, Synuclein, and Survival: G51D Mice Reveal a Shared Parkinson’s Pathway 28:38
  27. 445: Why Thymine Survived the UV: Photodamage Pathways Explained 26:55
  28. 444: Many-eyes or Sentinels? How Cost Curvature Shapes Collective Vigilance 24:40
  29. 443: 5D‑ASO boosts exon 51 skipping and restores dystrophin in DMD models 19:35
  30. 442: When pumps go missing: Ca2+ control of PMCA2 in Tmc1 deafness mutants 22:57
  31. 441: Evolutionary mapping of Cav1.3 functional sites 24:01
  32. 440: DENV-4: Suppressing DNA Repair and Causing Genome Damage 23:41
  33. 439: Coembedding Sequence and Structure: CLSS Maps the Protein Universe 23:08
  34. 438: Mapping AIRE: a proactive atlas of 9,790 missense variants 24:02
  35. 437: Cell villages and Dirichlet modeling map human cell fitness genetics 28:03
  36. 436: KIAP4 and the ARND family: building the Leishmania adhesion plaque 24:51
  37. 435: E. coli TGT binds two tRNAs — cryo-EM reveals dual engagement 19:03
  38. 434: High‑coverage genomes recast Japan's prehistoric demography 27:07
  39. 433: Lactate, HSP90α and the Mitochondrial Switch 23:55
  40. 432: Echovirus 18: Capsid opening releases the genome 18:29
  41. 431: KIAP4 and the ARND family: essential proteins for Leishmania–sand fly adhesion 21:33
  42. 430: Proterozoic Rise: Steady Diversification of Crown Eukaryotes 25:20
  43. 429: Validating the EAGL genetic literacy measure 23:49
  44. 428: Genetic regulation of plasma metabolites in people with HIV 28:03
  45. 427: When Genes Talk to Gut: Microbiome as Mediator of Metabolic Risk 25:13
  46. 426: ProtoCloud — Prototypical self-explaining model for single-cell analysis 16:53
  47. 425: BEAM: Bayesian reconstruction of metastatic migration histories 23:31
  48. 424: LECA's Ancient Interactome and Modern Disease 12:03
  49. 423: How GRN Topology Shapes the Genetic Architecture of Expression 25:10
  50. 422: Germline rDNA Variants and Human Complex Traits 20:13